Gestodene (GSD; 13p-ethyl-I 7a-ethynyl-l7p-hydroxy-4,15-gonadien-3-one) is the most potent synthetic progestin currently available and it is widely used as a fertility regulating agent in a number of contraceptive formulations because of its high effectiveness, safety and acceptability. The observations that this contraceptive synthetic progestin exerts estrogen-like effects besides that of its...
Se estudiaron las modificaciones producidas por la administración de diversas dosis de fármacos que interaccionan con el sistema calcio/calmodulina (Ca2+/Cam) sobre la conducta de receptividad sexual caracterizada por facilitación de lordosis inducida por progesterona (P) en ratas ooforectomizadas y pretratadas con estrógenos (E2). Se utilizaron ratas hembras de la cepa...
Epithelial Ovarian Cancer (EOC) is the most lethal gynecologic neoplasia since it is most commonly detected in an advanced stage, and often recurs after treatment, mainly because of the development of drug resistance (chemoresistance). EOC is clearly associated to hormonal and reproductive factors; however, no relationship has been found between...
