Cadmium has been regarded as one of the inflammation-related xenobiotics. This study was undertaken to examine the effects of low cadmium concentrations in HepG2 cells in the IL-1β, TNF-α, IL-6 and IL-8 expression, production of Hsp70 and the activation of nuclear factors AP-1 and NF-κB. Also, the participation of TNF-α...
The radical scavenging activity of Edaravone (3-methyl-1-phenyl-2-pyrazolin-5- one, EDA) and 26 derivatives has been studied using the density functional theory, in particular the M05-2X functional. In all cases both, the neutral and anionic forms were considered. We report for the first time their ionization potentials, proton affinities and pKas in...
El estrés crónico es considerado un factor de riesgo para el desarrollo de enfermedades crónico degenerativas que son consideradas problemas de salud pública. Aunque la asociación entre estrés fisiológico y alteraciones metabólicas es comúnmente aceptada, los mecanismos de daño aún no han sido dilucidados y comprendidos. El modelo de estrés...
The metabolic syndrome (MS) is a group of metabolic disorders, which increase the risk of cardiovascular disease and type 2 diabetes mellitus (DM2). Oxidative stress is one of the mechanisms involved in the association between MS and cardiovascular disease due to increased free fatty acids (FFA), triglycerides (TG) and leptin...
Aging is a complex and inevitable biological phenomenon that is characterized by the lose of several biochemical, structural and physiological functions in the organisms throughout their lifespan. Harman´s aging theory suggests that this process is the result of the overall accumulated damage on cellular macromolecules generated by free radicals. Now...
The hepatic diseases occupy the fifth cause of death in our country, and a 50% are due to the chronic ethanol intake (EtOH) being a problem of public health. The EtOH is oxidized by different enzymatic systems, the alcohol dehydrogenase (ADH), cytochrome P450 2E1 (CYP2E1) and catalase, this last one...
La lovastatina, es un medicamento que ayuda a reducir los niveles de colesterol en la sangre humana, y es producido industrialmente por el hongo Aspergillus terreus, en fermentación en medio líquido (FL). Estudios recientes en nuestro grupo han demostrado que al producir lovastatina en fermentación sólida (FS), la producción se...
In this up-to-date study we determined: 1st the generation of ROS in sperms and fluid epididymaries of Corynorhinus mexicanus bat in the period of maturation and sperm storage, 2nd the lipid peroxidation levels, such as the participation of epididimal fluid of this bat as inhibitor of lipid peroxidation, using washed...
Excitotoxicity occurs in response to the overactivation of glutamate receptors. Excitotoxicity is involved in neurodegenerative diseases and in acute brain diseases, such as brain injury and stroke. Glutamatergic signaling during excitotoxicity initiates with the loss of Ca2+ homeostasis that promotes, among other events, the overproduction of reactive oxygen species (ROS)...
BACKGROUND. Child malnutrition represents a major public health problem with physiological, psychological, and social short- and long-term implications. OBJECTIVE. To analyze the effects of nutritional status on cognitive function and its relationship with oxidative stress (OS) in mexican population aged 3 to 6 years. METHODS. Children were categorized into four...