Aging is a universal an irreversible physiological process that is related to continued deterioration as well as to the progressive loss of the organism's adaptive capacity. Senescence is a cellular phenomenon related to aging, which occurs when the cells reach their maximum replicative capacity and therefore irreversibly stop the cell...
Senescence phenotype can be achieved by multiple pathways. Most of them involve the activation of negative cell cycle regulators as well as a shift to an oxidative status. However, the exact participation of these events in senescence establishment and maintenance is not completely understood. In this study we investigated the...
La senescencia celular (SC) es un fenómeno en el que las células detienen su proliferación después de un número limitado de duplicaciones o como respuesta ante el estrés. En la SC hay cambios en la expresión génica, nula respuesta ante estímulos apoptóticos o mitogénicos, y el desarrollo de un secretoma...
Cellular senescence (SC) is a biological phenomenon that occurs in response to damage and has been linked to different biological and pathological processes. Much of the knowledge of cellular senescence has been described in fibroblasts; however, this is not the only cell type in which senescence occurs. The establishment of...