El incremento en el daño al ADN asociado con la edad, puede ser reconocido como la acumulación de mutaciones inducidas fisiológica y ambientalmente, junto con un debilitamiento de los sistemas de reparación del ADN. Uno de estos sistemas es el de reparación de bases por mal apareamiento (MMR), la principal...
Aging is characterized by the accumulation of damages in biomolecules during the organism lifespan. A large number of evidences suggest the existence of a physiological relationship between neurodegenerative diseases and aging. Huntington’s (HD), Alzheimer’s (AD) and Parkinson’s (PD) diseases are among the most important ones. All of them are characterizaed...
Sarcopenia is a syndrome characterized by the generalized and progressive loss of skeletal muscle mass and strength associated with aging. A sedentary lifestyle contributes to this condition, exacerbating and becoming a vicious cycle between difficulty in performing daily life tasks and disability, leading to total dependence and even death. Exercise...
La acumulación de daño por estrés oxidante sobre las biomoléculas como el ADN, es conocido como un factor que induce alteraciones en los mecanismos y estructura de la célula que podrían contribuir con el proceso del envejecimiento. El sistema de reparación de malos apareamientos tipo MMR corrige bases apareadas de...
Aging is a natural and inevitable process characterized by progressive physical and mental decline, presenting an accumulation of dysfunctional components, and ending with death. In particular, one of the health complications during aging is the failure in mobility and physical capacity, due to a progressive loss of skeletal muscle mass...
La senescencia es un fenómeno que se caracteriza por la detención permanente de la proliferación en respuesta a un daño o estrés, y por eso principalmente ha sido relacionado principalmente con el envejecimiento y enfermedades asociadas a este. Sin embargo, recientemente se ha demostrado su participación en otros procesos fisiológicos...
Advances in understanding cellular mechanisms in the aging process have allowed to delay it and increase longevity. Many studies indicates that aging may be influenced by several factors, including nutritional ones. Thus, it is known that dietetic control may be an important element in longevity, it is well known that...
The epididymis, a testosterone-dependent organ responsible for sperm maturation, has been shown to be damage as an organism is aging due to a decrease in testosterone serum levels, leading to an impact on sperm quality. In this context, it is not clear if sperm undergo apoptosis (a type of programmed...