Major depressive disorder or major depression is a common disorder that affects people worldwide and combines symptoms at psychological, physiological, and behavioural level. This disorder is predicted to be the second caus e of disability in 2020. Animal models of major depression caused by stress are relevant for the better...
Stress is the body's response to the loss of homeostasis by activating the hypothalamic-pituitary-adrenal gland (HHA) axis by releasing glucocorticoids (GCs) that allow the body to adapt. Intense or prolonged exposure to glucocorticoids has been associated with alterations in the hippocampus, a structure that in addition to expressing a large...
