Acetilcolinesterasa (AChE) y Butirilcolinesterasa (BChE) se han asociado con factores de riesgo para el síndrome metabólico (SM). Objetivo. El objetivo del presente trabajo fue evaluar el efecto de la nicotinamida (NAM) sobre las actividades, la expresión y el contenido de proteínas de las colinesterasas en un modelo de SM in...
Introduction: The nuclear enzyme poly (ADP-ribose) polymerase-1 (PARP-1) is essential for the repair of single-strand breaks in DNA by means of base excision repair and represents an important target in the therapy cancer. Inhibitors of PARP-1 have been shown to potentiate the cytotoxic effects of ionizing radiation and chemotherapeutic agents...
The disruption of redox state homeostasis, the overexpression of lipogenic transcription factors and enzymes induced by the increase in the consumption of lipogenic precursors contained in sweetened beverages are determinants of the development of nonalcoholic fatty liver disease. This study evaluated the action of nicotinamide (NAM) on the expression of...
Acetylcholinesterase, butyrylcholinesterase and paraoxonase - 1 are glycoproteins that besides regulating the neuromuscular cholinergic system and detoxify the body its activities are risk factors associated with metabolic syndrome (MS). The objective was to evaluate the participation of nicotinamide (NAM) on the activity and glycosylation pattern of circulating esterases in a...
