Increased plasma endotoxin levels in cirrhotic patients have been attributed to intestinal bacterial translocation and decreased liver clearance. In the presence of liver injury, endotoxin is able to induce inflammation, promoting further injury, and eventually, cirrhosis. Toll-like receptors (TLRs) participate in the recognition of pathogen-associated molecular patterns (PAMPs), and the...
The role of gram-negative bacteria in the pathogenesis of liver injury involves intestinal bacterial translocation and decreased liver clearance, leading to inflammation, tissue injury and eventually, cirrhosis. A similar damaging role has been credited to gram-positive bacteria. Toll-like receptors (TLRs) participate in the recognition of microorganismassociated molecular patterns (MAMPs) and...