Aging is a universal an irreversible physiological process that is related to continued deterioration as well as to the progressive loss of the organism's adaptive capacity. Senescence is a cellular phenomenon related to aging, which occurs when the cells reach their maximum replicative capacity and therefore irreversibly stop the cell...
La senescencia celular es un fenómeno en el que las células cesan su proliferación en respuesta a un número limitado de duplicaciones o a un estrés que induzca senescencia en forma prematura. Este fenómeno está asociado al envejecimiento y a múltiples enfermedades asociadas a la edad como cáncer y enfermedades...
Breast cancer is one of the most common neoplasia in the world and is the leading cause of cancer death in women in Mexico. Its high mortality is due mainly to its great metastatic capacity, which is associated with epithelial-mesenchymal transition (EMT). During this process, a decrease in the expression...
Triple-negative breast cancer (TNBC) is characterized by the lack expression of estrogen receptor (ER), progesterone receptor (PR) and the human epidermal growth factor receptor type 2 (HER2); these tumors are more invasive and metastatic, and therefore treatments are more unspecific and aggressive (chemotherapy). Recently, it has been proposed the possibility...
El principal factor de riesgo de las enfermedades neurodegenerativas es la edad, caracterizadas por el mal funcionamiento de las neuronas debido al microambiente pro-inflamatorio que se genera con la edad. El proceso inflamatorio puede tener un efecto neuroprotector o neurodegenerativo, dependiendo del tiempo de duración. Al no estar regulada, la...