Lovastatin is a drug of great industrial importance for reducing blood cholesterol levels, also in recent years is found as potential cancer therapeutic functions. Its conventional production takes place in SmF, however, in recent years has aroused great interest in the production SSF by high production, among other advantages over...
In previous work on the production of lovastatin by Aspergillus terreus, we found that the concentration of reactive oxygen species (ROS) increased to high levels precisely at the beginning of the production phase (idiophase) and that these levels were maintained throughout the idiophase. Furthermore, ROS were shown to regulate lovastatin...