High fructose intake through sugar-sweetened beverages induces metabolic and endocrine changes in adipose tissue (AT). It has been suggested that microRNAs (miRNAs) contained in extracellular vesicles (EVs) are some of the endocrine signals secreted by adipocytes, which can regulate diverse cellular processes, including adipocyte differentiation and metabolism. However, the effect...
Los receptores activados por proliferadores de peroxisomas (PPARs) son factores de expresión nuclear dependientes de ligando. Existen tres isoformas de PPAR, alfa (α), delta/beta (δ/β) y gamma (γ), todos ellos involucrados en el balance de metabolismo de lípidos y carbohidratos. Los PPARs representan un blanco terapéutico interesante para la prevención...
La inflamación es un proceso fisiológico protector que se activa en respuesta a una agresión físico-química para el restablecimiento del tejido afectado. En la inflamación, los macrófagos juegan un papel crítico mediante la producción de citocinas. Una respuesta inflamatoria excesiva y prolongada puede conducir a enfermedades asociadas al síndrome metabólico,...
Eicosapentaenoic acids (EPA) and docosahexaenoic (DHA) are omega-3 polyunsaturated fatty acids With the beneficial effects on preventing various diseases in which the inflammation plays a fundamental role. Since these omega - 3 fatty acids are ligands for PPARs, they could have an impact on metabolic activity. Therefore, they could exert...
The inflammatory process that is unleashed after an ischemic event has been associated with increased damage to the neural tissue; however, in recent years it has been observed that it also participates in mechanisms of protection and restoration of injured tissue through its stimulation with modified neural peptides such as...
Diabetes mellitus (DM) is one of the main chronic diseases at the present time and it is widespread throughout the world. It is defined as a set of metabolic disorders whose main characteristic is a persistent high blood glucose concentration (hyperglycemia), abnormal until reaching concentrations harmful to the physiological systems,...
Meduloblastoma is the most common malignant brain tumor developed during childhood and it accounts for 20% of total pediatric brain tumors. It is originated in the cerebellum, but it can invade other central nervous system regions. Besides tumoral cells, medulloblastoma is also composed by many groups of heterogeneous transformed cells....
Background: The cytomeglovirus infection is among the most feared complications in patients with immunological immaturity (preterm) and immunosuppressed (patients with bone marrow transplantation). The antigenemia or the polymerase chain reaction (PCR) tests have been routinely used for the detection of CMV in immunosuppressed patients. However, using these techniques for the...
Chronic kidney disease (CKD) is a global health problem that affects around 850 million people in the world. CKD is associated with the development of cardiac alterations that increase in more than 50% risk of mortality. In a previous study, it was demonstrated that during CKD progression, cardiac alterations including...
La DT2 es la principal causa de muerte en la población mexicana de entre 20 y 75 años. Además de la terapia farmacológica, la población hace uso de plantas reportadas como hipoglucemiantes en la medicina tradicional, como medio alternativo para su tratamiento. El objetivo del presente trabajo consistió en evaluar...